New study highlights what non-critically important antimicrobials are likely to be effective against chicken pathogens
A new study carried out by the ViParc team at Oxford University Clinical Research Unit has characterised antimicrobial resistance in chicken pathogens against 12 commonly used antimicrobials in the Mekong Delta of Vietnam. The study, led by Ms. Nguyen Thi Phuong Yen (ViParc laboratory scientist) investigated the antimicrobial susceptibility profiles of 58 pathogenic bacteria collected from diagnostic investigations of diseased chicken flocks in Dong Thap, including Ornithobacterium rhinotracheale (ORT), Gallibacterium anatis, and Avibacterium endocarditidis. Because antimicrobials are extensively used in chicken farms in the area, it is important to decide which antibiotics should be prioritized, whilst avoiding those of critical importance according to the World Health Organization (WHO). In the study the researchers analysed the distribution of susceptibility against 12 commonly used antimicrobials, and established a tentative interpretation of resistance. According to the results, doxycycline would theoretically be effective against A. endocarditidis (88.2% susceptibility and G. anatis infections (94.7% susceptibility) in most cases. A total of 86.4% ORT isolates were susceptible to oxytetracycline. In this study, non-critically important antimicrobials against which chicken pathogens are likely to be susceptible as a basis for treatment guidelines. Since there are not yet standardized international guidelines to determine whether a strain is resistance or not, this study illustrates the challenges in interpreting susceptibility testing results, and the need to establish such guidelines for veterinary pathogens. The full article can be accessed here: https://doi.org/10.3390/antibiotics9080499.